Cocoa nutrient for 'lethal ills'
By Michelle Roberts
BBC News health reporter
A nutrient in cocoa called epicatechin appears to lower the risk of
four common killer diseases, work suggests.
Among the Kuna people of Panama, who can drink up to 40 cups of cocoa
per week, rates of stroke, heart disease, cancer and diabetes are less
than 10%.
The Kuna also appear to live longer than other Panama inhabitants and
do not get dementia, a US scientist reports in Chemistry and Industry.
Experts stressed that genes and other lifestyle factors also play a part.
For most Kuna people, it is the only thing they drink from when they
are weaned to the day they die
Researcher Dr Norman Hollenberg
However, researcher Dr Norman Hollenberg, of Harvard Medical School,
says the cocoa chemical would benefit other populations too, including
the Western world, although he concedes there may be ethnic
differences.
And he acknowledges his studies are based on observations, so cannot
provide cast iron proof.
The Kuna people
He has been investigating the effects of epicatechin in hundreds of
elderly people from different cultures as well as hundreds of Kuna
people over the last 15 years.
"My interest began with the fact that Kuna people do not develop high
blood pressure," he explained.
"I was in search of protective genes but it turned out to be
environmental because, when they migrated to the mainland with all the
benefits of modern Western urban life, their blood pressure rose with
age and hypertension became quite common."
And death rates from ischemic heart disease, stroke, diabetes mellitus
and cancer followed suit, his published work in the International
Journal of Medical Sciences showed.
Dr Hollenberg believes the Kuna's local tipple is the key.
"For most Kuna people, it is the only thing they drink from when they
are weaned to the day they die."
He says his findings are so significant that epicatechin should be
considered essential in the diet and, therefore, classed as a vitamin.
'Essential vitamin'
At the moment, the science does not support epicatechin having an
essential role, but there is plenty of evidence to suggest it could
have a protective effect in the body.
Epicatechin, a type of flavonoid, is also found in teas, wine,
chocolate and some fruit and vegetables.
It may be that these diseases are the result of epicatechin deficiency
Daniel Fabricant of the Natural Products Association
One of its actions is thought to be through elevating levels of nitric
oxide in the blood, which helps relax the blood vessels and improves
blood flow.
And its antioxidant properties could explain how it might stop cancers.
Nutrition expert Daniel Fabricant, vice president of scientific
affairs at the Natural Products Association, said the link between
high epicatechin consumption and a decreased risk of lethal diseases
should be investigated further.
"It may be that these diseases are the result of epicatechin
deficiency," he suggested.
COCOA
The cacao tree was first cultivated in 250-900 AD by the ancient Maya
civilization in what is now Mexico and Central America
The Maya offered the beans to their Gods, used them currency and for
medicinal purposes to fight fatigue and gastrointestinal distress
A typical fruit pod of the tree contains approximately 25 to 75 cocoa beans
Flavanols like epicatechin are removed for commercial cocoas because
they tend to have a bitter taste.
Experts have also questioned whether it would be advisable and
feasible to eat large enough quantities of epicatechin-containing
foods such as wine and chocolate.
Dr Hollenberg, who is a scientific advisor to several big
pharmaceutical companies and has received financial backing for his
research from the M&M/Mars Company, believes there is scope for
nutritional companies to develop epicatechin supplements, such as
chocolate bars.
Indeed, Mars puts its Cocoapro logo on confectionery packaging to
signify products that have undergone its proprietary method for
processing cocoa beans to preserve flavonoid.
Paul Kroon of the Institute of Food Research said drug companies might
want to design new drugs to mimic epicatechin's structure and actions.
"But it's early days. And there is a danger with taking a reductionist
approach and trying to single out one particular chemical in foods.
Often its the mixture that is important," he said.
Professor Mary Engler from the University of California San Francisco,
who has also been studying epicatechin, said: "Well designed
experimental and clinical studies are needed to address the biological
importance of not only epicatechin but, also, other flavonoids that
are structurally different and found in many fruits, vegetables, and
beverages."
Ellen Mason, cardiac nurse at the British Heart Foundation, said:
"This is an interesting observation of a unique culture."
But she added: "We do not advise that people in the UK take up
drinking cocoa in high quantities in order to protect their hearts."
Story from BBC NEWS:
Published: 2007/03/11 00:30:47 GMT
http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/6430777.stm
subscribe to the newsletter
|